In this episode I visit with Dr. Amber Khanna of the University of Colorado about some of the “simple” congenital heart defects. We discuss atrial septal defects (ASD) and ventricular septal defect (VSD). We review useful testing to diagnose and evaluate these defects and the indications for closure.
Links:
2018 ACC/AHA Guidelines for the Management of Adults with Congenital Heart Disease
In this episode I visit with Dr. Eugene Yang to discuss the update to hypertension guidelines published in 2017 by the ACC/AHA. I asked him what were the major changes and which patients should be treated to a target of <130/80 and practical aspects to management.
Links:
Following up on our last discussion with Dr. Daniel Lenihan, we address the subject of immune checkpoint inhibitors and the associated cardio-toxicities. Immune checkpoint inhibitors “ease the brakes” of the immune system leading to dramatic improvements in some cancers, but rarely this can lead to profound cardiovascular compromise. Hyperlinks to references on apcardiology.com
References:
Cardiovascular toxicities associated with immune checkpoint inhibitors
Fulminant myocarditis with combination immune checkpoint blockade
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
