Following up on our last discussion with Dr. Daniel Lenihan, we address the subject of immune checkpoint inhibitors and the associated cardio-toxicities. Immune checkpoint inhibitors “ease the brakes” of the immune system leading to dramatic improvements in some cancers, but rarely this can lead to profound cardiovascular compromise. Hyperlinks to references on apcardiology.com
References:
Cardiovascular toxicities associated with immune checkpoint inhibitors
Fulminant myocarditis with combination immune checkpoint blockade
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
