I am joined by Shreyas Venkataraman to discuss the physical exam findings of aortic stenosis and how they can help us with the diagnosis and grading of aortic stenosis. We share 2 examples of heart murmurs, discuss likelihood ratios and the physical exam finding that is most consistent with severe aortic stenosis.

I visit with Robert Christenson PhD about the troponin assays and how they can be falsely positive from anti-body mediated interference. I present a case and we discuss the mechanisms which create the false positives (or negatives) with the assays, how manufacturers are trying to mitigate them and the emerging challenge of biotin supplements.

References (hyperlinks on apcardiology.com):

Arshed et al. Elevated Troponin I in the Absence of Coronary Artery Disease: A Case Report With Review of Literature. J Clin Med Res 2015

Krahn et al. High Percentage of False Positive Cardiac Troponin I Results in Patients with Rheumatoid Factor. Clinical Biochemistry. 1999